The concomitant use of diuretic and adreno-corticosteroids may increase the risk of electrolyte imbalance if excessive doses of Bisacodyl (Dulcolax) are taken. If so, electrolyte imbalance may increase the sensitivity to cardiac glycosides.
The concomitant use of other laxatives may enhance the gastrointestinal side effects of Bisacodyl (Dulcolax).